The Q Exactive Plus (Thermo Scientific) is a hybrid quadrupole-orbitrap instrument used for parallel reaction monitoring (PRM) in our targeted quantitative proteomics services. Orbitrap instruments are known for high m/z resolution, with values ranging from 17,500 to 280,000 on the Q Exactive Plus.
The advantage for PRM experiments on the Q Exactive Plus is the high-resolution product ion m/z scan and the increased specificity of detection this m/z resolution provides via smaller m/z tolerances in the data analysis.
