The TSQ Quantiva (Thermo Scientific) is a triple quadrupole instrument used exclusively for selected reaction monitoring (SRM) experiments for targeted quantitative proteomics. The advantage for SRM experiments on the TSQ Quantiva is rapid switching between transitions with a set dwell time. The result is that a large number of peptides can be measured in a single run with a consistent 1.5 cycle per second acquisition rate, which gives at least 20 data points for all chromatographic peaks.
Scheduling is used for all experiments based on the known retention times of targeted peptides. SRM on a triple quadrupole mass spectrometer remains a workhorse experiment for quantitative analysis with outstanding precision, lower limits of detection, and robust instrument operation.