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Orbitrap Tribrid Mass Spectrometers

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The Thermo Orbitrap Eclipse Tribrid system (Thermo Scientific) is the latest generation of the state-of-the-art Orbitrap mass spectrometry technology. The facility operates two Eclipse systems as well as two Orbitrap Fusion Tribrid instruments. The Orbitrap Tribrid systems combine a quadrupole mass filter with Orbitrap and linear ion trap mass analyzers in a novel configuration that maximizes ion transfer efficiency, allowing flexible combinations of different fragmentation techniques, scanning modes, and mass analyzers.

The quadrupole mass filter allows precursor ion selection, enabling parallel use of the mass analyzers and synchronous precursor selection for MS3 analysis. An ion-routing multipole serves as a higher-energy collisional dissociation (HCD) cell and also transfers ions efficiently between the Orbitrap and linear ion trap mass analyzers, allowing use of either mass analyzer in combination with any ion fragmentation technique.

The ultra-high-field Orbitrap mass analyzer has a resolving power of up to 500,000 FWHM and 45 Hz scan rate. A linear ion trap performs collision-induced dissociation (CID) and electron-transfer dissociation (ETD).

Thermo orbitrap eclipse tribrid system
Thermo orbitrap eclipse tribrid system